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Intellectual property

Intellectual property
Domestic or overseas Domestic Form of the I.P Patent
Patent no. US  12/605672 Registration no. 8030466
Patent no. EU  09173977.1 Registration no. 2305835
Name of the invention 3′-o-fluorescently modified nucleotides and uses thereof
Name of the invention(English)
I.P sector Others
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Attached file
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Commercialization information

Commercialization information
I.P Abstract & Summary The present invention relates to a DNA sequencing method using a nucleoside triphosphate with a fluorescent blocking group on its 32-OH end as a reversible terminator. Further, the present invention relates to sequencing-by-synthesis method using the mono-modified reversible terminator (MRT), the novel nucleotide monomer having a reversible fluorescent blocking group removable chemically or enzymatically at its 32-OH end. The sequencing method of the present invention facilitates sequencing of bases inserted by terminating extension of a nucleotide chain by the nucleotide monomer and then detecting fluorescence signal from 32-OH end. At this time, after analyzing the fluorescence signal, the blocking group conjugated to the 32-OH end can be effectively removed, indicating that a free 32-OH functional group can be successfully restored, so that the next monomer insertion is possible, making continuous sequencing possible.
Trade type of the I.P Rights transfer ( Overall )
10,000,000KRW ~ 10,000,000KRW
I.P stage Idea stage

#Nucleotide, #Quinching, #Expansion, #Detect, #a fluorescent signal, #a monomer, #Restore, #Removal